Catalyst N° 058 of 125 4 Apr 2025
Specialized AI brains for physical industry
with Sam Smith-Eppsteiner, partner, Innovation Endeavors
In this note
The question
Do physical industries need their own specialized AI products, or will the big general-purpose models eventually get good enough to do the job?
The answer
Smith-Eppsteiner’s theory is that there is real room for vertical AI products in industrial sectors, and that the reason has almost nothing to do with the models and almost everything to do with the customer’s data, which is fragmented across legacy systems, heavily unstructured and visual, and private, so the big model developers have never seen it. She is explicit that this is a theory rather than a finding. She cites cases running both directions and says plainly that nobody knows yet where it nets out.
03The argument
Her case lives on the supply side, meaning the customer’s data, and it has three parts. Industrial data is fragmented across legacy systems of record: in manufacturing alone a customer might run an ERP, an MES and a PLM, some of them on the company’s own servers, alongside piles of PDFs in SharePoint and email. The data is conceptually related but not practically linked. It is also unstructured, and unstructured in two different ways. Maintenance logs and similar text actually suit language models well, but blueprints, schematics, diagrams and 3D models look nothing like what the big models were trained on. And it is private, sitting on the customer’s cloud or on-premise rather than in the public domain, which is why she thinks general models read a technical drawing poorly: they have not seen enough of them. One scope qualifier is easy to lose here. Kann asked whether this is special to physical industries or true everywhere, and her answer was that there is probably some of it everywhere but more of it here, a difference of degree rather than kind, with the tooling older because there has barely been a category-defining product built for hardware engineers since the 1990s.
The catch is that the wall keeping the big labs out also keeps the startup out. Kann presses this hard: if the training data is private, you have to train on your customers’ data, they will not like that, and if you cannot get past it you never build a product that scales or improves. Smith-Eppsteiner says she thinks that is likely true, and her supporting evidence is commercial rather than technical. A founder she knows wrote training rights into every master services agreement from the start, found it very hard to get signed at first and now finds it boilerplate, and regards that clause as what made the product both performant and defensible. So the moat and the barrier to entry are the same object, and the defensibility argument is only as strong as a young company’s ability to win a contract term.
The demand-side leg is weaker, and she says so herself, calling the data points the main thrust. Her demand argument is the great crew change: experienced field engineers and technicians are retiring faster than they are being replaced, so the same work must be done by fewer people and the expertise sitting in their heads needs capturing. Kann’s objection is that this is a genuine macro driver that plays out over decades, a slow-release painkiller with no urgency behind it. She concedes it is a long-term trend and counters with customer sentiment rather than purchasing behavior: in oil and gas, customers described it to her as a major pain point and a real fear. On whether a specialized product can be built economically, she reports founders getting to roughly 70% to 90% of required performance on prompt engineering alone, leaving open whether that is sufficient or whether a person fills the remaining gap. Past that the approaches scatter. She hears that embedding works poorly on non-textual data, that fine-tuning is the natural next step, and that some teams intend to build their own models, and she describes the field as very early innings.
The last turn is economic, and it is where Kann is most skeptical. Plenty of these applications are obviously useful without being large; his example is siting optimization for energy developers, which he thinks is genuinely valuable and not a venture-scale business by itself. Her answer is about stickiness and expansion rather than proof. Upstream work like siting and permitting runs on third-party external data, and when they talked to customers those customers sounded ready to switch tools, whereas a product deeply integrated with a customer’s own data, with a model trained on it, is much harder to leave. Expansion comes from embedding into the transaction layer sitting above the workflow, her example being the fines for missed delivery appointments in trucking. Underneath sits a business model choice with real consequences: sell the technology like traditional software, or sell the work and absorb the AI cost yourself, which she finds most attractive where the customer already outsources that function. Either way inference cost is not trivial, so she expects gross margins in the 40% to 70% range rather than the 90% of classic software, and layering services on top lowers margin further while raising the dollar value of the contract. The prize she names is a budget shift: industrial companies have limited willingness to pay for software but spend heavily on labor, so a product sold as labor augmentation reaches a much larger pool. Whether that actually happens, she says, is still to be seen.
04What you need to know first
- Systems of record
- The core databases a company runs on. ERP is enterprise resource planning, covering finance, orders and inventory; MES is manufacturing execution, covering what is happening on the shop floor; PLM is product lifecycle management, covering designs and their revisions. In these industries they are typically old, separate from one another, and sometimes running on the company’s own hardware rather than in the cloud.
- The specialization ladder
- Four increasingly expensive ways to make a general model work on your problem: prompt engineering, meaning carefully written instructions, and the cheapest option; embedding, converting your documents into a form the model can search; fine-tuning, further training an existing model on your data; and training a model of your own. Most of the disagreement among the founders she talks to is about which rung to stop at.
- Inference cost
- What it costs to run the model every time someone uses the product. Traditional software has almost no equivalent, which is why she expects structurally lower margins here.
- The great crew change
- The industry’s term for the retirement wave among experienced field engineers and technicians, and for the undocumented expertise leaving with them.
05Details worth keeping
- She lays out four categories of company: the knowledge base, which she prefers to describe as making sense of complexity rather than as search; agentic AI that does the work; copilots for engineering and discovery; and compliance and risk mitigation.
- The knowledge-base example is concrete. On a construction site, answering “when are the light fixtures for the second floor arriving?” means parsing the phrase, finding the right fixture on the blueprints, identifying the specific item and then looking it up in a supply chain system. Conceptually trivial, and today it takes several people across several systems.
- Hubflow automates scheduling between truckers and receiving warehouses for one side of the transaction while the other side sees its normal workflow unchanged. A company called Conduit is automating the other side, so the two may end up negotiating appointments with each other.
- Cadstrom, an early investment of hers, is building a copilot for electrical engineers doing circuit board design, starting at verification and validation because engineers dislike that work. The sequence it performs, inferring the engineer’s intent, parsing each component’s limits, modeling how the board would behave, then deciding on and running the simulations, is what she thinks transfers to structural and other engineering domains. The transcript garbles the company name to “Strom.”
- WeaveBio, from her firm’s health and bio portfolio, is, she says, significantly speeding up preparation of Investigational New Drug applications for the US Food and Drug Administration and improving their quality. She uses it as her example of a single narrow workflow that is a large opportunity on its own terms.
- One company she describes breaks a relatively simple task into nine separate agents, some of which check and test the answers the others produce.
- Adoption depends on not threatening the user. Starting with work the end user dislikes doing gets them on your side; otherwise you get the familiar tension where the executive sees the return and the process engineer fears for their job.
- Kann’s extension is that the largest budget is neither software nor labor but capital: maintenance spending, or a claim to extend asset life so the capital budget falls by 10%. Both agree it is very hard to sell upfront, for the timescale reason recorded below.
06Claims worth citing
All as stated on 2025-04-04. Everything here comes from a venture investor describing her own portfolio and her conversations with founders, not from measurement. The model-capability and cost figures date fastest.
- Prompt engineering alone gets a specialized product to roughly 70% to 90% of required performance, described as widely variable. founders, relayed by Smith-Eppsteiner
- Expected gross margins of roughly 40% to 70% for these businesses, against about 90% for traditional software, driven by inference cost. She attaches a condition to the figure: there are ways to manage inference cost, and she hopes it comes down over time. Smith-Eppsteiner
- Industrial customers have limited willingness to pay for software but spend heavily on labor, making labor the much larger budget to sell into. Whether these products actually reach that budget is explicitly unproven. Smith-Eppsteiner
- General models handle industrial text such as maintenance logs well but read technical diagrams, blueprints and 3D models poorly, because that material was not in their training data. Smith-Eppsteiner
- The last company to build a multi-billion-dollar, category-defining product selling to hardware engineers was started in the 1990s, possibly the 1980s. Smith-Eppsteiner
- One company uses nine separate agents to complete a single simple task, including compliance checking and testing of the answer. Smith-Eppsteiner
- On proving value: demonstrating the same work done with 20% of the people takes a week or two, while a ten-year asset-life claim takes thirty years to confirm. Smith-Eppsteiner
- DeepSeek and others have shown a path to cheaper, smaller models that a startup could viably build. She frames this as her hope, not a result. Smith-Eppsteiner
07Where it’s contested
- The thesis is offered as unsettled, at both ends of the conversation. She opens with cases running both ways: high-growth general-purpose AI tools losing deals to vertical specialists, and law firms using Anthropic rather than a legal-specific tool like Harvey. Her stated position is that she does not know where this nets out, and the episode ends without resolving it.
- Whether the data conditions are actually distinctive. Pressed by Kann on whether siloed PDFs are special to physical industry, she scales the claim back to a difference of degree rather than kind. The argument rests on that qualified version, not the stronger one.
- The moat is also the barrier. Kann’s version is strong: a company unable to obtain rights to train on customer data has no scalable product. She accepts it only as likely true. Either way it makes the defensibility case contingent on commercial terms rather than on technology.
- The demand-side argument is weak by both accounts. Kann calls the retirement wave a slow-release painkiller. She accepts it is a long-term trend and answers with what customers say rather than with what they buy.
- Venture scale is unresolved. Kann’s worry is a landscape of hundreds of small companies solving real problems in markets too small to produce generational businesses. Her reply is a framework for judging stickiness and expansion, not evidence that the large outcomes are there.
- No consensus on how to build one. She reports founders saying incompatible things about embedding, fine-tuning and building their own models.
- The evidence base is investor-sourced throughout. The named examples are her own investments or her firm’s portfolio companies, and the performance figures come from founders describing their own products. Nothing in this episode is independently measured or third-party tested.